First Month on Mounjaro - Weight Loss Week by Week
Mounjaro is among our most popular weight loss treatments, and for good reason. Its active ingredient, tirzepatide, helps curb appetite, making it easier to stick to a low-calorie diet without constant hunger—a common hurdle in achieving and sustaining weight loss. Studies show that with a 15mg weekly dose (the maximum maintenance dose), users can lose up to 22.5% of their starting weight over 72 weeks. Here's our short article about what you can expect during the first month of treatment. Aside from looking at results you can expect we also go over the experience from real patients who are undergoing the treatment to help you get a sense of how the treatment works and how it feels to undergo it.
All examples and experiences have been gathered from customer reviews and this is important to keep in mind when reading. The personal experience does not necessarily reflect results in clinical trials and remember, each person’s journey is unique, so your weekly progress may vary from others’.
Week 1: Starting Mounjaro
The first dose is 2.5mg of tirzepatide.
Weight Loss Results
Early results from users indicate significant weight loss, with one user reporting a 5 lb (2.2 kg) drop while consuming 1,700 calories per day. Another review mentioned a 7 lb (3.5 kg) loss by the end of the first week, emphasizing how Mounjaro made physical activities like climbing stairs easier.
Appetite and Food Thoughts
Many users describe a noticeable decrease in appetite after just a few days on Mounjaro. For instance, one reviewer shared that by midweek, they ate about half their usual amount. Another noted "reduced food noise" for the first four days, experiencing fewer intrusive food-related thoughts.
Side Effects and Management
Common side effects include mild nausea and, for some, mild diarrhea. Users found that sips of cold water, fresh air, and brushing their teeth helped manage nausea. One user noted they felt better after a couple of days without major symptoms.
Physical/Mental Changes
Patients commonly reported feeling more balanced in their energy levels and fewer cravings, including those for alcohol. A user described feeling "fabulous" and not hungry, experiencing enhanced energy and mood in their first week.
Pharmacist comments
Although everyone is different and will have a different experience when taking mounjaro I have frequently hear from patients mention reduction in food-noise which not only helps them eat less but also focus on other areas of their life. Some describe that their thoughts about food sometimes felt like an addiction and that tha mounjaro helped them break free from the cycle, offering a sense of control.
Week 2: Continued Adjustments and Results
The second dose is typically 5mg of tirzepatide
Weight Loss Results
Users generally continue to see weight loss results, with one person noting a drop to 57.6 kg from 58.7 kg by the end of the second week. Another lost 4 lbs in the first week, but weight loss continued, though slightly slower than initially.
Appetite and Food Thoughts
Appetite suppression remains a common experience, with many noting they only eat half of what they typically would. As one patient shared, "I wasn’t super hungry but could eat" in the second week, though the strongest suppression was in the first few days.
Side Effects and Management
Side effects tend to stabilize, with users describing them as mild. For some, hunger returned briefly around days five or six after injection, a common adaptation response as the body adjusts.
Physical/Mental Changes
Subtle improvements in mobility and energy are noted, with some users attributing weight loss to water weight and reduced inflammation. The benefits are more physical, with few dietary or activity changes required for these results.
Pharmacist comments
Mounjaro mimics GLP-1 and GIP hormones in the intestine to regulate appetite and blood sugar. Some patients report that its effects may feel slightly reduced towards the end of the week, a sensation also reflected in patient reviews. This is one reason for the incremental increase in dosage—this approach helps the body adjust while keeping side effects minimal and manageable.
Weeks 3-4: Solidifying Progress and Notable Effects
The third and fourth dose are typically 7.5mg and 10mg of tirzepatide respectively.
Weight Loss Results
By the end of the first month, many users report sustained weight loss. One user noted a 21.7 lb loss after four weeks, attributing this to appetite suppression and consistent use.
Appetite and Food Thoughts
Users describe feeling consistently full with fewer food-related thoughts. As one patient shared, "Food chatter is at an all-time low," which helps them eat smaller meals without feeling deprived.
Side Effects and Management
Some experience mild fatigue, cold sensations, and slight headaches, though these side effects are generally manageable. For others, side effects are minimal or even nonexistent by the end of the first month.
Physical/Mental Changes
Positive mental shifts include a sense of achievement and enhanced motivation. With weight loss becoming visible, users feel encouraged, reporting an increase in energy and reduced midday fatigue.
Pharmacist comments
The first 4 weeks are there to make the body used to the medication. The incremental increase in dosage tends to make side effects more manageable and after 4 weeks on the treatment majority of patients should notice significant changes in bodyweight.
