Mounjaro Frequently Asked Questions answered by a Pharmacist

This FAQ on Mounjaro has been carefully compiled and fact-checked by Alessandro Grenci, Superintendent Pharmacist to ensure accuracy and reliability. It is designed to provide clear, evidence-based answers to common questions, using up-to-date medical information and regulatory guidelines. The content has been structured for easy navigation, allowing readers to quickly find relevant details. Every effort has been made to present information in a balanced and objective manner, with a focus on clarity and precision. This resource aims to support informed decision-making by offering well-researched and professionally reviewed insights.

What is Mounjaro and how does it work for weight loss?

Mounjaro is a prescription medication containing tirzepatide, which works as a dual GIP and GLP-1 receptor agonist for weight loss. It functions by activating receptors for two hormones in the body: GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1). This dual action helps reduce appetite, slow down digestion, and regulate blood sugar levels. Mounjaro makes you feel fuller faster, alters your body's reaction to food, and improves insulin sensitivity. By decreasing hunger and food intake while also enhancing metabolic processes, Mounjaro leads to significant weight loss when combined with a balanced diet and exercise.

When will Mounjaro be available for weight loss treatment in the UK?

Mounjaro is currently available for weight loss treatment in the UK through private prescriptions and patient group direction (PGD). Patients can access it via licensed healthcare providers. The medication was launched in the UK in February 2024 and has received regulatory approval for treating obesity alongside type 2 diabetes. Private providers are not bound by NHS guidelines, allowing broader access to eligible patients with a BMI of 30 or greater. While the phased rollout on the NHS is expected to begin in early 2025, private prescriptions and PGD remain the primary options for weight loss treatment at this time.

Who is eligible for Mounjaro weight loss treatment in the UK?

To be eligible for Mounjaro weight loss treatment in the UK, patients must meet specific criteria. Individuals should have a body mass index (BMI) of 30 kg/m² or higher, indicating obesity. Alternatively, those with a BMI between 27 and 30 kg/m² may qualify if they also have weight-related health conditions, such as high blood pressure, high cholesterol, or prediabetes. Patients must be aged between 18 and 75 and should not have any contraindications that could interact negatively with Mounjaro. A healthcare professional will assess eligibility based on medical history and current medications during a consultation.

What is the recommended dosage for Mounjaro?

The recommended dosage for Mounjaro begins at 2.5 mg, administered once weekly for the first four weeks. This initial dose allows the body to adjust to the medication and minimizes potential side effects. After this period, the dosage is typically increased every four weeks, following a structured schedule: 5 mg, 7.5 mg, 10 mg, 12.5 mg, and finally the maximum maintenance dose of 15 mg weekly. Patients may remain at lower doses if they experience side effects or achieve satisfactory weight loss results at those levels. The maximum dose of 15 mg is considered the most effective for weight loss but is not suitable for everyone and must be prescribed by a healthcare provider. Always follow your doctor’s instructions for safe and effective treatment.

How is Mounjaro administered?

Mounjaro is administered as a subcutaneous injection, meaning it is injected under the skin. Patients typically use a pre-filled injection pen to self-administer the medication once a week. The recommended injection sites include the abdomen, upper thighs, and, with assistance, the back of the upper arm. It is important to rotate injection sites to avoid irritation and soreness. Before administering Mounjaro, patients should ensure they follow proper preparation steps, including washing their hands and checking the pen for any damage.

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What are the potential side effects of Mounjaro?

Mounjaro can cause a range of side effects, from mild to serious. The most common side effects include nausea, diarrhoea, vomiting, constipation, decreased appetite, and abdominal pain. Some patients may experience injection site reactions, such as redness, bruising, or itching. More serious but less common side effects can include pancreatitis, gallbladder problems, hypoglycemia (especially when used with insulin), and severe digestive issues that may lead to dehydration and kidney problems. Mounjaro also carries a boxed warning for the potential risk of thyroid cancer, based on animal studies. Most side effects are typically mild and may subside as the body adjusts to the medication, but patients should consult their healthcare provider if side effects persist or become severe.

How much weight can one expect to lose with Mounjaro?

Clinical trials have shown significant weight loss results with Mounjaro (tirzepatide). On average, patients can expect to lose 10% to 20% of their body weight over the course of treatment. After 72 weeks on the highest maintenance dose of 15mg, participants lost up to 22.5% of their starting body weight. In the first month, patients may see a weight reduction of about 4% of their body weight, increasing to around 6% after two months. However, individual results can vary depending on factors such as dosage, diet, exercise, and personal health conditions. It's important to note that the best weight loss results were observed after 72 weeks of treatment, suggesting that Mounjaro's full effects manifest over an extended period.

How long does it take to see results with Mounjaro?

Most Mounjaro users begin to see initial results within the first few weeks, with reduced appetite and improved blood sugar control. However, significant weight loss typically becomes noticeable after 1-3 months of consistent use. Research shows that patients can expect to lose around 1% of their body weight per week for the first 4 weeks. By 3 months, users may see a 5-10% reduction in starting weight, with some achieving 10-15% weight loss by 6 months. The median time to reach at least a 5% weight loss was 12 weeks with Mounjaro 10 mg and 15 mg doses. For optimal results, it's crucial to combine Mounjaro with a balanced diet and regular exercise.

Is Mounjaro available on the NHS for weight loss?

Mounjaro (tirzepatide) is expected to be available on the NHS for weight loss in England starting from spring 2025. However, its availability will be limited and rolled out gradually over a 12-year period due to high costs and the current lack of support services. Initially, it will be offered to patients with the most significant health risks, including those with a BMI of at least 35 kg/m² and at least one weight-related health condition. The NHS plans to provide Mounjaro to a minimum of 220,000 people living with obesity within a 3-year period. Access will begin through specialist weight management services in spring 2025, followed by primary care services in summer 2025. It's important to note that eligibility criteria and prioritization may change as the rollout progresses.

What is the cost of Mounjaro treatment in the UK?

The cost of Mounjaro treatment in the UK varies depending on the dosage. For NHS patients with type 2 diabetes, it is available for the standard prescription charge of £9.90 per item, unless they qualify for an NHS prescription charge exemption, in which case it would be free. However, for weight loss purposes, it is primarily available through private clinics and online pharmacies. Private costs typically range from £150 to £200 per month for a subscription plan, with some providers offering more competitive pricing starting from £110 per month. The first four-week supply of the lowest dose (2.5 mg) can cost around £180, with prices increasing for higher doses. It's important to note that while some providers may offer lower prices, they may not include additional support or guidance, which could be valuable for long-term success in weight management.

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How does Mounjaro compare to other weight loss medications?

Mounjaro (tirzepatide) has shown superior efficacy compared to other weight loss medications in clinical trials. In head-to-head studies, Mounjaro demonstrated greater average weight loss than Wegovy (semaglutide), with patients losing up to 22.5% of their body weight on the highest dose of Mounjaro compared to 15% with Wegovy. Mounjaro's dual action on GLP-1 and GIP receptors contributes to its enhanced effectiveness in reducing appetite and regulating metabolism. Clinical data indicates that a higher percentage of patients achieved significant weight loss milestones with Mounjaro compared to other medications, with 96.3% of participants losing at least 5% of their starting weight on the 15mg dose. Additionally, Mounjaro has shown superior efficacy in reducing HbA1c levels, making it particularly beneficial for patients with type 2 diabetes.

Can Mounjaro be used alongside other weight loss treatments?

Mounjaro (tirzepatide) should not be used alongside other weight loss treatments. It is not advised to take more than one weight loss medication simultaneously unless specifically instructed by a healthcare professional. Combining Mounjaro with other weight loss medications could potentially lead to increased side effects or interactions. If you're currently using another weight loss treatment, it's crucial to inform your doctor before starting Mounjaro. Your healthcare provider may need to adjust your treatment plan or discontinue other weight loss medications before prescribing Mounjaro. Always consult with your doctor or pharmacist about any medications, including over-the-counter drugs and herbal supplements, you're taking before starting Mounjaro treatment.

Are there any dietary restrictions while using Mounjaro?

While using Mounjaro, there are no strict dietary restrictions, but following a balanced and healthy diet is crucial for maximizing weight loss results. It's recommended to focus on whole foods, including lean proteins, healthy fats, whole grains, and plenty of fruits and vegetables. Users should aim to reduce their calorie intake by around 600 calories per day compared to their recommended daily amount. It's advisable to limit or avoid ultra-processed foods, added sugars, refined carbohydrates, and foods high in saturated fats to reduce the likelihood of side effects like nausea and diarrhoea. Proper hydration is also important, and it's suggested to sip fluids between meals rather than during them. While there are no specific foods that must be completely avoided, being mindful of your diet and making healthier choices will support your weight loss journey with Mounjaro.

How often do you need to take Mounjaro?

Mounjaro (tirzepatide) is administered as a once-weekly injection for weight loss. The medication should be taken on the same day each week, ideally at the same time, to maintain consistent levels in the body and maximize effectiveness. When starting Mounjaro, you'll begin with a 2.5mg dose for the first 4 weeks, after which your healthcare provider will typically increase the dose. The dosage is usually increased every 4 weeks until you reach the most effective dose for you, which could be up to 15mg weekly. It's crucial to follow your healthcare provider's instructions regarding the dosing schedule and not to adjust the frequency or amount without consulting them first.

What happens if you miss a dose of Mounjaro?

If you miss a dose of Mounjaro, you should take it as soon as possible within 4 days of the missed dose. If more than 4 days have passed since the missed dose, skip it and take your next dose on the regularly scheduled day. It's important to never take two doses of Mounjaro within 3 days of each other. After taking the missed or next scheduled dose, resume your regular once-weekly dosing schedule. If you miss two or more doses in a row, consult your clinician before restarting treatment, as they may need to lower your dosage.

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Can you stop taking Mounjaro once you've reached your weight loss goal?

Yes, you can stop taking Mounjaro once you've reached your weight loss goal, but it's crucial to do so under medical supervision. When you stop Mounjaro, your appetite may increase and you might experience some weight regain, as the medication's effects on appetite regulation cease. Studies have shown that patients can regain up to 14% of their lost body weight after discontinuing Mounjaro. To minimize weight regain, it's recommended to gradually reduce the dose rather than stopping abruptly, and to maintain a healthy diet and exercise routine. Your doctor may suggest a maintenance plan or alternative treatments to help sustain your weight loss after stopping Mounjaro.

Are there any long-term studies on the effects of Mounjaro?

Yes, there are long-term studies on the effects of Mounjaro (tirzepatide) for weight loss. The SURMOUNT-4 trial investigated the long-term effects of tirzepatide over 88 weeks. Participants initially lost an average of 20.9% of their body weight during a 36-week treatment period. The study then continued for another 52 weeks to assess the long-term effects. Another clinical trial evaluated Mounjaro's efficacy over 72 weeks, demonstrating significant weight loss of up to 22.5% of initial body weight. Additionally, the FDA approval of Mounjaro was based on evidence from nine clinical trials involving 7,769 patients with type 2 diabetes mellitus, providing further long-term safety and efficacy data. However, as Mounjaro is a relatively new medication, ongoing studies are still being conducted to gather more comprehensive long-term data.

How does Mounjaro affect appetite and food cravings?

Mounjaro significantly affects appetite and food cravings by mimicking two important hormones: GLP-1 and GIP. It suppresses appetite by slowing down gastric emptying and signalling fullness to the brain, leading to reduced food intake and smaller meal portions. Many patients report a dramatic reduction in hunger and cravings, particularly for unhealthy or high-calorie foods. The medication also helps users feel full more quickly and for longer periods, which can result in decreased overall calorie consumption. Some patients describe experiencing 'food freedom,' allowing them to focus on smaller, healthier portions and resist overeating. However, it's important to note that while Mounjaro can help with physical hunger, it may not completely address emotional eating triggers.

What lifestyle changes are recommended while using Mounjaro?

While using Mounjaro, several lifestyle changes are recommended to maximize weight loss results. A balanced diet rich in lean proteins, fruits, vegetables, and whole grains is crucial, with a focus on creating a calorie deficit of around 600 calories per day. Regular physical activity is essential, aiming for at least 150 minutes of moderate-intensity exercise per week. Staying hydrated by drinking 6 to 8 servings of fluid daily, primarily water, is important, but it's advised to avoid drinking 30 minutes before and after meals to avoid slowing down digestion even further. Improving sleep quality and reducing stress levels can also contribute to better weight loss outcomes. Additionally, using trackers to monitor progress, including weight, waist measurements, exercise, and meals, can help maintain motivation and identify effective strategies.

Can Mounjaro be used by patients with type 2 diabetes?

Yes, Mounjarocan be used by patients with type 2 diabetes. In fact, it was initially approved for treating type 2 diabetes before being considered for weight loss treatment. Mounjaro works by helping to control blood sugar levels in people with type 2 diabetes by increasing insulin production, reducing liver sugar production, and slowing down digestion. Clinical trials have shown that Mounjaro is effective in lowering HbA1c levels and fasting blood glucose in type 2 diabetes patients. For patients with type 2 diabetes in the UK, Mounjaro may be prescribed when triple therapy with metformin and two other oral antidiabetic drugs is ineffective, not tolerated, or contraindicated, and when specific BMI criteria are met. It's important to note that Mounjaro should be used in conjunction with diet and exercise for optimal blood sugar control in type 2 diabetes patients.

Are there any contraindications for using Mounjaro?

Mounjaro (tirzepatide) is contraindicated in several cases. It should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients who are allergic to tirzepatide or any other ingredients in Mounjaro should avoid its use. The medication is also contraindicated during pregnancy and breastfeeding. Mounjaro is not indicated for use in patients with type 1 diabetes mellitus. Those with severe gastrointestinal disease, including severe gastroparesis, should exercise caution as Mounjaro has not been studied in this population. Additionally, patients with certain eye problems such as diabetic retinopathy or macular oedema should use Mounjaro with caution under appropriate monitoring.

How does Mounjaro differ from GLP-1 receptor agonists?

Mounjaro(tirzepatide) differs from traditional GLP-1 receptor agonists in its dual-action mechanism. While GLP-1 receptor agonists like Wegovy and Ozempic only target the GLP-1 receptor, Mounjaro is a dual agonist that activates both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors. This unique approach enhances insulin secretion, reduces glucagon levels, and slows gastric emptying, potentially leading to more comprehensive metabolic effects. Mounjaro's dual-agonist mechanism is believed to provide superior blood sugar control and potentially greater weight loss compared to single-agonist GLP-1 medications. Clinical trials have shown that Mounjaro can result in an average weight loss of 15-20% of body weight, which is generally higher than what is typically seen with traditional GLP-1 agonists.

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What is the success rate of Mounjaro for weight loss?

Mounjaro has shown a high success rate for weight loss in clinical trials. In a 72-week study, 89.4% to 96.3% of participants lost at least 5% of their starting weight, depending on the maintenance dose. The highest dose (15mg weekly) led to an average weight loss of 22.5% of initial body weight. Another study found that Mounjaro patients experienced 47% greater relative weight loss compared to those using Wegovy after 72 weeks. However, individual results may vary, and success rates in real-world settings might differ from clinical trials. The medication's effectiveness is enhanced when combined with a healthy diet and regular exercise.

How long can someone stay on Mounjaro treatment?

Mounjaro can be used for long-term weight loss treatment under medical supervision. Clinical studies have followed patients for up to 72 weeks (about 1.5 years) when taking Mounjaro for weight loss. For patients prescribed Mounjaro privately, it can be taken indefinitely if tolerated well and deemed appropriate by the clinical team. The duration of treatment depends on individual weight loss goals and circumstances, with some people choosing to stop when they reach their target weight while others continue for maintenance. If you don't lose at least 5% of your starting weight after 6 months on your maintenance dose, your doctor may reassess the treatment's benefits.

What monitoring is required while using Mounjaro?

Patients using Mounjaro require regular monitoring to ensure safety and effectiveness. Your healthcare provider will track your weight loss progress, aiming for at least a 5% reduction in starting weight after 12 weeks on your maintenance dose. They will also monitor for potential side effects and adjust the dosage if necessary. Regular check-ups may include measuring BMI, body measurements, and assessing overall health improvements. Blood tests might be conducted to monitor blood sugar levels, especially for patients with type 2 diabetes. It's crucial to maintain open communication with your healthcare provider throughout the treatment, reporting any concerns or unexpected effects promptly.

Can Mounjaro be used during pregnancy or breastfeeding?

Mounjaro (tirzepatide) is not recommended for use during pregnancy or breastfeeding. Clinical trials have not been conducted on pregnant women, and animal studies have shown potential risks to fetal development. The drug is contraindicated during pregnancy, and women of childbearing potential are advised to use contraception while on Mounjaro. For breastfeeding mothers, there is no data on the presence of tirzepatide in human milk or its effects on breastfed infants. Due to the lack of safety information, healthcare professionals typically advise against using Mounjaro while breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, it's crucial to consult with your doctor about alternative diabetes management options.

How does Mounjaro affect metabolism?

Mounjaro significantly impacts metabolism by enhancing insulin sensitivity and improving the body's ability to process glucose. It stimulates the pancreas to produce more insulin in response to glucose, ensuring efficient carbohydrate processing and steady blood sugar levels. This balanced insulin production reduces the likelihood of fat storage in visceral areas. Mounjaro also enhances lipid metabolism, aiding in the breakdown of stored fats, particularly in adipose tissue. By lowering liver glucose production, it minimizes the risk of excess fat storage in visceral regions, promoting a healthier body composition. As individuals shed excess weight with Mounjaro, their metabolism often becomes more efficient, leading to better energy conversion from nutrients.

What are the storage requirements for Mounjaro?

Mounjaro should be stored in a refrigerator at a temperature between 2°C and 8°C until use. Once removed from the refrigerator, unopened Mounjaro pens can be kept at room temperature (up to 30°C) for up to 30 days, after which they should be discarded. It is crucial not to freeze Mounjaro, as this renders the medication unsafe for use. Mounjaro pens should be kept in their original packaging to protect them from light. Always check the expiration date before using the medication. If a pen has been frozen, it should not be used.

Can Mounjaro be used by patients with a history of eating disorders?

Mounjaro can be challenging for patients with a history of eating disorders. While some individuals report positive experiences with reduced binge eating behaviours, there are concerns that weight loss medications like Mounjaro might trigger or exacerbate eating disorders, such as anorexia nervosa, in susceptible individuals. Healthcare providers are advised to carefully evaluate patients' conditions before prescribing such medications. Some patients have been denied access to Mounjaro due to their eating disorder history. It is crucial for patients with a history of eating disorders to consult closely with healthcare professionals and consider psychological support alongside any treatment. Generally, caution is recommended when prescribing Mounjaro to individuals with a history of eating disorders.

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How does BMI affect eligibility for Mounjaro treatment in the UK?

In the UK, BMI plays a significant role in determining eligibility for Mounjaro treatment. Generally, Mounjaro is prescribed for individuals with a BMI of 30 kg/m² or higher, or those with a BMI between 27 and 30 kg/m² if they have weight-related health conditions like high blood pressure or type 2 diabetes. For NHS eligibility, a BMI of at least 35 kg/m² is typically required, along with at least one obesity-related health condition. NICE guidelines also suggest that individuals from certain ethnic backgrounds may be eligible at a lower BMI due to increased health risks. The NHS plans to prioritize those with the greatest clinical need during the rollout. Mounjaro is available privately with a prescription or via Patient Group Direction (PGD) for those who meet the criteria.

What support is provided to patients using Mounjaro for weight loss?

Patients using Mounjaro for weight loss can expect structured support in line with regulatory guidelines. This includes participation in "wraparound care," which focuses on dietary improvements, nutritional guidance, and increased physical activity to ensure sustainable weight loss outcomes. Prescribing processes require thorough health assessments, including verified BMI and medical history, often through face-to-face or video consultations, to ensure patient safety and suitability for treatment. Patients are also monitored closely by healthcare teams to address any concerns, adjust dosages, and integrate Mounjaro into a broader weight management plan. Additionally, healthcare providers are expected to maintain clear notes and documentation of supplies to ensure accountability and transparency. This holistic approach ensures that patients receive safe and effective care tailored to their individual needs.

Are there any age restrictions for Mounjaro use?

Mounjaro is suitable only for adults aged 18 to 75. It is not recommended for individuals under the age of 18 or over 75. Additionally, Mounjaro should not be used by pregnant or breastfeeding women. For personalized guidance, consulting a healthcare professional is essential.

How does Mounjaro impact muscle mass during weight loss?

Mounjaro can impact muscle mass during weight loss due to its appetite-suppressing effects, which may lead to a reduced calorie intake. This reduction can cause the body to break down muscle tissue for energy, especially if protein intake is inadequate or if there is rapid weight loss. While Mounjaro does not directly target muscle tissue, the overall weight loss process can result in some lean mass loss. However, studies indicate that for every kilogram of lean mass lost, participants typically lose more fat mass, suggesting that Mounjaro primarily targets fat tissue. To mitigate muscle loss, it is recommended to maintain adequate protein intake and engage in regular resistance training exercises. Regular monitoring of body composition and consulting with healthcare professionals can also help manage muscle mass during treatment.

Can Mounjaro be used by patients with kidney or liver problems?

Mounjaro can be used by patients with mild to moderate kidney problems, but it is not recommended for those with end-stage renal disease due to limited clinical experience. Patients with kidney issues should be monitored closely, as Mounjaro can cause gastrointestinal side effects leading to dehydration, which may worsen kidney function. For liver problems, Mounjaro has not been shown to cause liver damage, but caution is advised in patients with hepatic impairment due to limited clinical experience. It is essential for patients with kidney or liver issues to consult their doctor before starting Mounjaro treatment to assess the risks and benefits.

What is the recommended exercise regimen while using Mounjaro?

The recommended exercise regimen while using Mounjaro includes a combination of cardiovascular exercises, strength training, and flexibility exercises. Cardio activities such as walking, cycling, or swimming should aim for at least 150 minutes of moderate exercise per week. Strength training, like bodyweight exercises or weightlifting, should be done 2-3 times a week to build muscle and support metabolism. Flexibility exercises like yoga or Pilates can help improve movement and reduce injury risk, and should also be done 2-3 times a week. It's important to start slowly and gradually increase intensity to avoid overexertion. Always consult a healthcare provider for personalized advice.

How does Mounjaro affect blood sugar levels?

Mounjaro affects blood sugar levels by mimicking two hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This action increases insulin secretion, which helps lower blood sugar levels, and reduces glucagon production, preventing excessive blood sugar elevation. Additionally, Mounjaro slows gastric emptying, which further aids in regulating blood sugar by slowing glucose absorption from food. Clinical trials have shown that Mounjaro significantly lowers HbA1c levels and fasting blood glucose in patients with type 2 diabetes. By improving insulin sensitivity and reducing liver sugar release, Mounjaro effectively manages blood sugar levels. Overall, these mechanisms contribute to better blood sugar control and are beneficial for managing type 2 diabetes.

Are there any known drug interactions with Mounjaro?

Mounjaro can interact with several medications, which may affect its efficacy or increase the risk of side effects. Key interactions include diabetes medications like insulin, sulfonylureas, and glinides, as these can increase the risk of hypoglycemia (low blood sugar) when used together. Additionally, Mounjaro may reduce the effectiveness of oral birth control pills by slowing down their absorption. It should not be used with other GLP-1 receptor agonists like Ozempic or Victoza to avoid increased side effects. Mounjaro can also affect the absorption of other oral medications, such as warfarin, requiring closer monitoring.

What happens if weight loss plateaus while using Mounjaro?

If weight loss plateaus while using Mounjaro, it's a common occurrence and not a cause for concern. This plateau happens as your body adjusts to the reduced caloric intake and slower metabolism, which can temporarily halt weight loss progress. To overcome this, consider reassessing your diet and exercise routine. Ensure you're following a balanced diet with high-fibre foods and lean proteins, and increase your physical activity by incorporating both aerobic and resistance training. If the plateau persists, consulting with a healthcare provider about adjusting your dosage or treatment plan may be beneficial. Regular follow-ups with healthcare providers can also help address any underlying issues and provide additional strategies for overcoming the plateau.

Can Mounjaro be prescribed by GPs in the UK?

Currently, Mounjaro cannot be prescribed by GPs in the UK for weight loss, within the NHS. It is typically available through specialist weight management services or private prescriptions from licensed providers. GPs are not yet authorized to prescribe Mounjaro, and any discussions about this medication should be directed towards specialist services or private pharmacies offering it. However, some GPs may be trained to prescribe Mounjaro in the future as part of broader NHS plans. For now, patients seeking Mounjaro for weight loss should explore specialist referrals or private options.

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How does Mounjaro compare to bariatric surgery for weight loss?

Mounjaro and bariatric surgery are both effective for weight loss, but they work differently. Mounjaro leads to an average weight loss of about 22-26% over several months, while bariatric surgery typically results in a 15-30% weight loss in the first year, potentially reaching up to 38kg lost after four years. Bariatric surgery involves a one-time procedure with permanent anatomical changes, whereas Mounjaro is an ongoing medication that is reversible if stopped. Bariatric surgery often requires significant lifestyle changes and carries surgical risks, whereas Mounjaro has fewer risks but may cause gastrointestinal side effects. The choice between the two depends on individual health needs and preferences. Overall, bariatric surgery can lead to more dramatic weight loss but involves more risks and permanent changes.

What is the role of specialist weight management services in Mounjaro treatment?

Specialist weight management services play a crucial role in Mounjaro treatment by providing the initial access to the medication. These services are essential for ensuring that patients receive appropriate support and monitoring while using Mounjaro, as they often involve a team of healthcare professionals such as specialist doctors, nurses, and dietitians. Initially, Mounjaro will only be available through these specialist services before a wider rollout to other healthcare settings. The services focus on diet, nutrition, behavioural changes, and lifestyle adjustments to complement the medication's effects. This comprehensive approach helps manage demand on healthcare services and ensures safe prescribing practices. By offering a structured environment, these services help patients achieve optimal weight loss outcomes with Mounjaro.

How does Mounjaro affect cholesterol levels?

Mounjaro may help improve cholesterol profiles by reducing LDL ("bad") cholesterol levels, which is beneficial for cardiovascular health. This effect is part of its broader impact on reducing cardiovascular risk factors, including blood pressure and blood sugar control. While Mounjaro itself does not directly target cholesterol, the weight loss it facilitates can also contribute to improved lipid levels. Additionally, studies have shown that Mounjaro-treated patients experience improvements in lipid levels alongside significant weight loss. Overall, Mounjaro's impact on cholesterol is indirect but positive, primarily through weight loss and overall metabolic improvements. It is important to maintain a healthy diet alongside Mounjaro treatment to maximize these benefits.

Can Mounjaro be used by patients with a history of pancreatitis?

Mounjaro has not been studied in patients with a history of pancreatitis, and it should be avoided or used with caution in these individuals. If you have had pancreatitis recently or have chronic pancreatitis, Mounjaro may not be suitable for you. Patients with a past history of pancreatitis may be able to use Mounjaro under close medical supervision, but the risk of recurrence is a concern. It is crucial for patients with a history of pancreatitis to discuss their medical history with a healthcare provider before starting Mounjaro. If pancreatitis occurs while taking Mounjaro, the medication should be discontinued promptly. Monitoring for signs of pancreatitis, such as severe abdominal pain and vomiting, is essential for early intervention.

What is the maximum duration of Mounjaro treatment?

The maximum duration of Mounjaro treatment for weight loss typically extends to two years, depending on individual circumstances and weight loss goals. Treatment duration is typically determined by how well the medication works for the patient and whether they need ongoing support to maintain weight loss. Mounjaro is designed as a long-term treatment, with significant weight loss results often seen around the 6-18 month mark. The decision to continue or stop treatment is made in consultation with a healthcare provider. It's important to note that stopping Mounjaro may lead to weight regain, emphasizing the need for sustained lifestyle changes.

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How does Mounjaro affect energy levels and physical activity?

Mounjaro (tirzepatide) can affect energy levels in various ways depending on the stage of treatment. Initially, some patients may experience fatigue due to reduced calorie intake or low blood sugar, but this is typically temporary and resolves as the body adjusts to the medication. Over time, as weight loss progresses and metabolic health improves, many patients report increased energy levels and enhanced physical performance. This improvement is often linked to better glucose regulation, reduced physical strain from excess weight, and more efficient nutrient utilization.

In terms of physical activity, Mounjaro’s benefits extend to improved stamina and endurance. Weight loss reduces joint stress and inflammation, making movement easier and less tiring. Additionally, regular exercise while using Mounjaro can further boost energy levels by improving cardiovascular health and muscle tone. Overall, Mounjaro’s impact on energy is multifaceted, with initial challenges often giving way to long-term benefits as treatment progresses.

What psychological effects, if any, are associated with Mounjaro use?

Mounjaro, a GLP-1 receptor agonist, can have both positive and negative psychological effects. On the positive side, successful weight loss with Mounjaro can boost self-esteem and self-confidence, enhance mood, and reduce anxiety related to health concerns and body image. However, some individuals may experience mood changes, including anxiety and depression, although these are rare and often mild to moderate. The medication's impact on hormonal balance and blood sugar levels can also contribute to anxiety. Additionally, there is a potential risk of disordered eating behaviours due to its appetite-reducing effects. It is important for users to be aware of these psychological impacts and seek support if needed.

How does Mounjaro impact skin elasticity during rapid weight loss?

Mounjaro impacts skin elasticity during rapid weight loss by causing sagging skin, a common side effect due to the skin's inability to contract quickly enough after significant weight reduction. The skin, composed of collagen and elastin, loses elasticity when stretched during weight gain and may not fully recover after rapid weight loss, leading to loose skin. Factors such as age and genetics also influence skin elasticity. Treatments like skin tightening and surgical procedures are often recommended to address this issue. Mounjaro's effectiveness in weight loss can lead to significant body mass reduction, exacerbating the problem of loose skin. As a result, many individuals opt for cosmetic solutions to improve skin appearance after using Mounjaro.

Can Mounjaro be used in combination with other obesity medications?

Mounjaro can be used in combination with other medications, but caution is advised, especially with certain obesity or diabetes medications. For instance, it can be used alongside insulin, but the insulin dosage may need to be adjusted to prevent hypoglycemia. Other weight loss medications like Wegovy and Saxenda work similarly to Mounjaro, but it's generally recommended to use one treatment at a time under medical supervision. Combining Mounjaro with other medications should be done under the guidance of a healthcare provider to ensure safety and effectiveness. Always consult with a healthcare professional before starting or combining any medications.

What follow-up care is required after completing Mounjaro treatment?

After completing Mounjaro treatment, follow-up care is crucial to maintain weight loss. Patients should continue healthy lifestyle habits, including a balanced diet and regular exercise, as weight regain is common once the medication is stopped. Regular monitoring by healthcare professionals can help assess whether restarting treatment is necessary if significant weight gain occurs. In some cases, dose reduction may be recommended if weight loss plateaus. Support from dieticians and lifestyle services can also aid in maintaining weight loss. Additionally, ongoing support from healthcare providers is essential to ensure that any necessary adjustments are made to prevent weight regain.

How does Mounjaro affect nutrient absorption and vitamin levels?

Mounjaro can affect nutrient absorption and vitamin levels by reducing appetite, leading to lower food intake, which may result in deficiencies of essential vitamins and minerals such as vitamin B12, vitamin D, and calcium. This reduced intake can be exacerbated by dietary changes or faster weight loss, which may deplete stored nutrients. To mitigate these effects, maintaining a balanced diet rich in whole foods and considering supplements for nutrients like B12, vitamin D, and calcium is recommended. Regular monitoring of vitamin levels through blood tests is also advised to identify deficiencies early. Additionally, staying hydrated supports nutrient absorption and overall health. It is important to consult with a healthcare professional before starting any supplements to ensure they are appropriate for your specific needs.

Ordering from medino

What are the steps from purchasing to dispatch for the consultation process?

Product Selection: The customer chooses the product based on provided guidelines and advice in the product description. If you wish to start the therapy you should choose Mounjaro 2.5mg.
Risk Assessment Form: Before checkout, the customer must complete a risk assessment questionnaire.
Pharmacist Review: Once payment is made, the pharmacist reviews the risk assessment form to verify eligibility.
Medical Records Check: The pharmacist may check medical records and, if necessary, contact the customer’s GP, which can extend processing time.
Evidence Submission: If eligible, the pharmacist requests biometric evidence (weight, height, blood pressure, and pulse) via email or WhatsApp.
Further Verification: If the submitted evidence doesn’t align with the reported details or falls outside the eligibility criteria, the pharmacist will contact the customer for clarification or reject the order.
Consultation: If all details are satisfactory, the pharmacist schedules a video or phone consultation to gather additional information, give advice and address any questions.
Final Confirmation & Dispatch: Once the pharmacist is satisfied, the order is confirmed both verbally and via email, and the medication is shipped.

How are customers contacted throughout the consultation when ordering from medino?

Customers are contacted via: Email & WhatsApp: For biometric evidence submission. Phone or Video Call: To complete the consultation and discuss additional information. Email Confirmation: To inform the customer of the order status and final approval.

If further clarification is needed, the pharmacist will reach out via phone or email before proceeding with the order.

What kind of documents do customers need to provide when ordering from medino?

Photo ID: A clear photo of an official identification document (passport or driving license). Full-Body Photo: A picture of the customer holding their ID, showing their body shape (wearing clothes that don’t hide body shape).

What temperature can Mounjaro be kept at during shipping?

Mounjaro is packed in temperature-controlled packaging designed to maintain a temperature between 2°C and 8°C, and to prevent temperature excursions for up to 1–2 days, depending on external conditions. For this reason, we use 24-hour Royal Mail delivery. If delivery takes longer, we utilize Eli Lilly's temperature excursion tool to confirm the medication's safety and ensure its expiration date remains unaffected. This verification process is valid for several days, provided the temperature remains below 30°C.

There you have it, our comprehensive list of frequently asked questions and answers. Did we miss anything? Or do you need further guidance? Please contact us at info@medino.com.

Written by Christian Jakobsson