Zentiva Co-Codamol 32 Tablets stands as a reliable pain relief option for adults in need of swift and effective reprieve from moderate to severe discomfort. Particularly beneficial for individuals dealing with headaches, migraines, toothache, and rheumatic pain, Zentiva Co-Codamol fuses the efficacy of paracetamol and codeine to significantly mitigate pain. Its effectiveness in managing acute pain highlights its value as a temporary solution for pain control. Prior to making a decision, it's important for consumers to consider its short-term application and potential side effects.

Key features

Rapid Pain Relief: Delivers swift relief, helping users engage in daily activities with less pain.
Dual Active Ingredients: The presence of both paracetamol and codeine enhances pain reduction more effectively than when used separately.
Versatile Use: Applicable for various types of pain such as migraines, dental pain, and muscular discomfort.
Short-term Treatment: Tailored for acute pain management, recommended for use up to three days.
Dependency Awareness: Contains codeine, which could lead to dependency with prolonged use.

What symptoms or conditions can be treated with Zentiva Co-Codamol?

Zentiva Co-Codamol effectively addresses various painful and febrile conditions like headaches, migraines, neuralgia, toothache, sore throat, colds, influenza, dysmenorrhoea, and rheumatic pain.

What are the benefits of using Zentiva Co-Codamol?

It provides swift and effective pain relief, with its nature allowing for easy consumption and rapid action.

How does Zentiva Co-Codamol work?

The synergy of paracetamol and codeine reduces prostaglandins in the brain and blocks pain signals, respectively, alleviating pain and discomfort.

Are there any known side effects?

Some common side effects include constipation, nausea, dizziness, and drowsiness. While rare, serious side effects like allergic reactions and breathing problems can occur.

Can I drive after taking Zentiva Co-Codamol?

It's recommended to avoid driving or operating heavy machinery due to potential dizziness or drowsiness caused by the medication.

Will I get addicted to these tablets?

There's a risk of addiction if Zentiva Co-Codamol is used continuously for more than three days. It's crucial to adhere to dosage guidelines.

Can I take these tablets if I’m taking other medication?

Consult a healthcare professional before combining Zentiva Co-Codamol with other medications, especially those containing paracetamol or sedatives.

Patient information leaflet

Ingredients

Each tablet contains 500mg of paracetamol and 8mg of codeine phosphate.

excipients: Maize starch, Povidone, Potassium sorbate, Microcrystalline cellulose, Stearic acid, Magnesium stearate, Talc, pregelatinised starch, Purified water

Usage and Instructions

Always read the label.

Adults and children aged 16 to 18 years: One to two tablets every 6 hours when necessary up to a maximum of 8 tablets in 24 hours.

Children aged 12 to 15 years: One tablet every six hours when necessary to a maximum of four tablets in 24 hours.

Warnings

Paediatric population: Not recommended for children under 12 years of age.
Sensitive patients: Exercise care when administering to elderly, those with prostatic hypertrophy, hypothyroidism, inflammatory or obstructive bowel disorders, Addison's disease, myasthenia gravis, or those on CNS depressants.
Paracetamol caution: Use cautiously in severe renal or hepatic impairment. Overdose risk is higher in non-cirrhotic alcoholic liver disease.
Flucloxacillin interaction: Increased risk of high anion gap metabolic acidosis (HAGMA) when taken with paraceatamol, especially in patients with severe renal impairment, sepsis, malnutrition, chronic alcoholism, or those taking maximum daily doses of paracetamol. Close monitoring recommended.
Dosage advice: Do not exceed the recommended dose. Avoid taking with other paracetamol-containing products. Seek immediate medical advice in case of overdose.
Convulsive disorders: Use with caution in patients with convulsive disorders.
Addiction risk: This medicine can cause addiction if taken for more than 3 days. Withdrawal symptoms can occur if stopped abruptly.

CYP2D6 metabolism: Codeine is metabolized to morphine by CYP2D6. Variations in metabolism can lead to insufficient analgesia or increased risk of toxicity.
Post-operative use in children: Reports of life-threatening events in ultra-rapid or extensive metabolizers after tonsillectomy/adenoidectomy.
Children with compromised respiratory function: Not recommended for use in children with conditions that may worsen respiratory function.
Sedative medicines risk: Concomitant use with sedatives like benzodiazepines can cause sedation, respiratory depression, coma, and death. Use the lowest effective dose and shortest duration possible. Monitor closely for respiratory depression and sedation.
Alcohol interaction: Concomitant use with alcohol can cause sedation, respiratory depression, coma, and death. Not recommended to use with alcohol.
Medical advice for use: Use under medical advice for patients with mild-to-moderate hepatocellular insufficiency or severe renal insufficiency. Monitor blood count, liver function, and renal function after prolonged use.

Contraindications:

• Hypersensitivity to the active substances or any of the other excipients.

• In all paediatric patients (0-18 years of age) who undergo tonsillectomy and/or adenoidectomy for obstructive sleep apnoea syndrome due to an increased risk of developing serious and life-threatening adverse reactions

• In women during breastfeeding • In patients for whom it is known they are CYP2D6 ultra-rapid metabolisers

Side Effects

Codeine can produce typical opioid effects including constipation, nausea, vomiting, dizziness, light-headedness, confusion, drowsiness and urinary retention. The frequency and severity are determined by dosage, duration of treatment and individual sensitivity. Tolerance and dependence can occur, especially with prolonged high dosage of codeine.